![]() |
JOURNAL TOOLS |
Publishing options |
eTOC |
To subscribe |
Submit an article |
Recommend to your librarian |
ARTICLE TOOLS |
Publication history |
Reprints |
Permissions |
Cite this article as |
Share |


YOUR ACCOUNT
YOUR ORDERS
SHOPPING BASKET
Items: 0
Total amount: € 0,00
HOW TO ORDER
YOUR SUBSCRIPTIONS
YOUR ARTICLES
YOUR EBOOKS
COUPON
ACCESSIBILITY
Journal of Neurosurgical Sciences 2020 Sep 24
DOI: 10.23736/S0390-5616.20.05023-7
Copyright © 2020 EDIZIONI MINERVA MEDICA
language: English
Survival benefit of concomitant chemoradiation in adult supratentorial primary glioblastoma. A propensity score weighted population-based analysis
Ignacio JUSUE-TORRES 1 ✉, Alicia HULBERT 2, 3, Kevin BARTON 4, Edward MELIAN 1, 5, Douglas E. ANDERSON 1, Alfredo QUINONES-HINOJOSA 6, Vikram C. PRABHU 1
1 Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, IL, USA; 2 Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA; 3 Cancer Center, University of Illinois at Chicago, Chicago, IL, USA; 4 Hematology Oncology, Loyola University Stritch School of Medicine, Maywood, IL, USA; 5 Radiation Oncology, Loyola University Stritch School of Medicine, Maywood, IL, USA; 6 Department of Neurosurgery, Mayo Clinic College of Medicine, Jacksonville, FL, USA
BACKGROUND: This population study aims to assess the impact of the implementation of the original Stupp protocol on overall survival in patients with new-diagnosed supratentorial primary GBM.
METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to study the survival of histologically confirmed adult supratentorial GBM patients diagnosed between 1998 and 2016. Kaplan-Meier, and a univariate and propensity-score weighted multivariate Cox proportional hazard model adjusted for age at diagnosis, sex, race, marital status and extent of resection was used to assess the survival of patients prior to implementation of the Stupp protocol in 2005 (Pre-Stupp) and following implementation of the Stupp Protocol until 2016 (Post Stupp).
RESULTS: 6,390 patients satisfied inclusion exclusion criteria. Median survival times were 13 months for the Pre-Stupp and 15 months for Post-Stupp groups (p<0.001). The 1-,2-, 5- and 10- year survival rates for the Pre-Stupp group were 51, 18, 5 and 2% respectively compared to 59, 27, 8 and 4% on the Post-Stupp group. Propensity-score weighted analysis showed a lower mortality risk for patients who underwent concomitant chemoradiation during the Post-Stupp era [HR 0.77, 95% CI 0.62-0.94]. There was a 42 percent relative reduction in the risk of death for patients treated during the Post-Stupp era.
CONCLUSIONS: This population-based propensity-score study with long-term follow-up suggests that the implementation of the Stupp protocol in 2005 had a positive impact on the survival of patients with supratentorial GBM. This “real-world” analysis validates the results of the original randomized control trial on which this protocol is based.
KEY WORDS: SEER registry; Glioblastoma; Survival; Temozolomide; Concomitant chemoradiation; Stupp protocol