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Journal of Neurosurgical Sciences 2019 Sep 23

DOI: 10.23736/S0390-5616.19.04758-1


language: English

Intramedullary spinal cord tumors: the value of intraoperative neurophysiological monitoring in a series of 57 cases from two Italian centres

Delia CANNIZZARO 1, Cristina MANCARELLA 2, Davide NASI 3, 4, 5, Maria Pia TROPEANO 1 , Carla D. ANANIA 1, Giovanni CATALETTI 1, Daniela MILANI 1, Enrica M. FAVA 6, Reza GHADIRPOUR 3, Francesco COSTA 1, Franco SERVADEI 1, Maurizio FORNARI 1

1 Department of Neurosurgery, Humanitas Clinical Research Hospital, Neurocenter, Rozzano, Milan, Italy; 2 Department of Neurosurgery, IRCSS, Neuromed, Pozzilli, Italy; 3 Department of Neurosurgery, University Hospital of Parma, Parma, Italy; 4 Department of Neurosurgery, Institute for Scientific and Care Research “ASMN” of Reggio Emilia, Reggio Emilia, Italy; 5 Department of Neurosurgery, Umberto I General Hospital, Università Politecnica delle Marche, Ancona, Italy; 6 Neurosurgery, Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Rozzano, Milan, Italy


BACKGROUND: Intramedullary spinal cord tumors are rare lesions of the central nervous system. Anatomical, molecular and radiological features are well defined, but correct management is still matter of debate. Pertinent literature has reported conflicting opinions regarding the use of intraoperative electrophysiological monitoring (IONM) in the surgical treatment of this kind of lesions, recently. We report a retrospective study from two Italian centres, in order to highlight the usefulness of IONM in the management of intramedullary lesions.
METHODS: We performed a retrospective review of patients with intramedullary spinal tumor who underwent surgical resection from February 2011 to February 2018 in two different institutions. Clinical and radiological data, lesion features, timing of symptom onset and IONM findings were record ed . The IONM includ ed somatosensory-evoked potentials(SSEP), motor-evoked potentials(MEP) and D-Wave whenever possible. We evaluated the outcome according to the Modified McCormick scale. We also evaluated the accuracy and relevance of surgical outcomes for each evoked potential(SSEP, MEP, D-Wave).
RESULTS: A total of 57 patients were included. A gross total removal was achieved in 46 cases. Neurological follow-up was assessment at 3 days, and 3 and 6 months after surgery. Comparing the preoperative status and 6 months follow-up: the M-McCormick scale showed a neurological stability for 30 patients (52.63%), a worsening of neurological status for 7 patients (12.28%) and an improvement for 20 patients (35.08%). IONM presented high accuracy (sensibility of 100% and specificity of 95.65%) and significantly pred icted postoperative permanent motor d eficits(P<0.0001; AUC=0.978). D-Wave appeared to have significant greater predictive value than MEP and especially SSEP alone(0.967 vs 0.722 vs 0.542; P = 0.044 and P<0.001 respectively).
CONCLUSIONS: The gold standard in the intramedullary lesion treatment is maximal safe resection with good neurological outcome, as shown in our patients. The use of IONM is helpful in intramedullary tumors resection in order to minimize postoperative neurological deficits and our analysis suggests that the use of D-Wave presents a statistically significant higher accuracy for predicting postoperative deficits than SSEP and MEP alone.

KEY WORDS: Spinal tumor; Intraoperative monitoring; Intramedullary tumors; D-wave; Motor evoked potentials; Somatosensory evoked potentials

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