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JOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


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Journal of Neurosurgical Sciences 2018 Mar 26

DOI: 10.23736/S0390-5616.18.04322-9

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Incidence and risk factors of neurosurgical site infections: results of a prospective multicenter cohort study on 6359 surgeries

Laura VALENTINI 1 , Francesca CHIAFFARINO 1, Nicoletta BONFANTI 2, Marilou PANNACCI 1, Paolo CORTELLAZZI 3, Caterina UBERTI-FOPPA 4, Marika FURLANETTO 1, Francesco DI MECO 1, Luca MASSIMI 5, on behalf of the Passis Group

1 Department of Neurosurgery, Fondazione Istituto Neurologico “Carlo Besta” (FINCB), Milan, Italy; 2 Department of Neurosurgery, Ospedale di Circolo di Varese, Varese, Italy; 3 Department of Neuroanesthesia and Intensive Care, Fondazione Istituto Neurologico “Carlo Besta” (FINCB), Milan, Italy; 4 Department of Infectious Diseases, Scientific Institute, Ospedale San Raffaele, Milan, Italy; 5 Department of Paediatric Neurosurgery, Policlinico Gemelli, Rome, Italy


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OBJECTIVES: Neurosurgical surgical site infections (SSI) are life-threatening complications, requiring medical treatment and additional surgeries and remain a substantial cause of morbidity. In order to identify the incidence and the main risk factors for SSI, we developed the Prophylaxis with Antibiotic protocol for neuroSurgical Site Infections Study (PASSIS), a prospective observational multicenter cohort study for examining a large number of neurosurgical procedures.
METHODS: The study PASSIS involved four Italian Neurosurgical Departments applying the same antibiotic prophylaxis (ABP) protocol on 6359 consecutive neurosurgical procedures. In high-risk conditions (intra-operative contamination and/or post-operative cerebro-spinal fluid (CSF), and/or subcutaneous drainage and/or post-operative hyperpyrexia), and in presence of wound complication (CSF leak and/or CSF collection and/or wound diastasis), a prolongation protocol was prescribed.
RESULTS: The crude rate of SSI in the whole series was and 1.7% for patient and 1.5% for procedure. Patient related SSI risk factors: Younger patients (≤14 years) had a significantly higher SSI risk compared with older patients (RR: 2.17; CI 95%: 1.13- 4.14). Patients underwent two surgeries were at increased SSI risk (RR: 3.80; CI 95% 2.33-6.18), and the risk increased with the number of surgeries. Surgeries lasting longer than 3 hours (RR: 2.27; CI 95% 1.15-4.50), undergoing two or more surgeries and the presence of prosthetic implants (RR: 2.40; CI 95% 1.53- 3.77) were procedure related SSI risk factors positively associated with SSI. In high-risk conditions and in wound complication as defined previously, ABP prolongation showed limited efficacy (RR:1.97; CI 95% 1.21-3.22 and 9.31; CI 95% 5.90-14.68 respectively).
CONCLUSIONS: The subjects submitted to complicated, repeated, long lasting craniotomies, especially if experiencing postoperative deterioration, display the higher risk of SSIs, as a final life threatening complication. In order to reduce the SSI rate, further studies should address to design tailored prophylaxis protocols for each high risk situation as hereby defined; the wound complications deserve an increased microbiological surveillance, focusing the attention on the timing and source of infections.


KEY WORDS: Surgical site infection (SSI) - Prophylactic antibiotic - Neurosurgery - Risk factors

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Publication History

Article first published online: March 26, 2018
Manuscript accepted: March 5, 2018
Manuscript received: January 4, 2018

Cite this article as

Valentini L, Chiaffarino F, Bonfanti N, Pannacci M, Cortellazzi P, Uberti-Foppa C, et al; the Passis Group. Incidence and risk factors of neurosurgical site infections: results of a prospective multicenter cohort study on 6359 surgeries. J Neurosurg Sci 2018 Mar 26. DOI: 10.23736/S0390-5616.18.04322-9

the Passis Group

Corresponding author e-mail

laura.valentini@istituto-besta.it