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A Journal on Neurosurgery

Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
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Journal of Neurosurgical Sciences 2017 Dec 04

DOI: 10.23736/S0390-5616.17.04274-6


language: English

Clinical correlates of subventricular zone-contacting glioblastomas: a meta-analysis

Akshitkumar M. MISTRY

Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA


INTRODUCTION: The clinical and molecular correlates of glioblastomas (GBMs) contacting the subventricular zone (SVZ+ GBM) are unknown. We aimed to reveal any such correlates that may help explain their increased GBM malignancy.
EVIDENCE ACQUISITION: A meta-analysis was, therefore, conducted to assess whether tumor’s MGMT promoter methylation status, IDH mutation status, volume, and extent of resection as well as patients’ age at diagnosis and preoperative Karnofsky performance status score (KPS) correlate with SVZ contact by GBM. In addition, available imaging of GBM patients in The Cancer Imaging Archive was assessed for SVZ contact and their corresponding clinical and molecular variables were obtained through The Cancer Genome Atlas (TCGA) database.
EVIDENCE SYNTHESIS: Twenty-one studies were identified through PubMed and EMBASE database search. 257 patients who had imaging were included from the TCIA/TCGA database. MGMT promoter methylation status (summary odds ratio, OD, 1.18 [0.84-1.66], p=0.34), IDH mutation status (OD: 0.63 [0.20-1.99], p=0.43), and patients’ age of diagnosis (summary mean difference, MD, 0.10 years [-1.85, 2.05], p=0.92) did not associated with SVZ contact of the GBM. However, SVZ+ GBMs were significantly larger than SVZ- GBMs (MD: 17.3 cm3 [8.70-25.8], p<0.0001). SVZ+ GBM patients had lower KPS scores (MD: -3.33 [-5.31-(-1.35)], p=0.001) and were half as likely to receive a gross total resection (OD: 0.50 [0.40-0.64], p<0.00001).
CONCLUSIONS: Additional, large studies that rigorously control for all the known clinical and molecular prognosticators, especially extent of resection and preoperative KPS scores, are needed to evaluate whether SVZ contact by GBM independently influences survival.

KEY WORDS: Ventricular-subventricular zone - V-SVZ - Subventricular Zone - SVZ - Glioblastoma - Glioma

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Publication History

Article first published online: December 04, 2017
Manuscript accepted: November 23, 2017
Manuscript received: November 14, 2017

Cite this article as

Mistry AM. Clinical correlates of subventricular zone-contacting glioblastomas: a meta-analysis. J Neurosurg Sci 2017 Dec 04. DOI: 10.23736/S0390-5616.17.04274-6

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