Home > Journals > Journal of Neurosurgical Sciences > Past Issues > Articles online first > Journal of Neurosurgical Sciences 2017 Nov 20

CURRENT ISSUE
 

ARTICLE TOOLS

Publication history
Reprints
Cite this article as

JOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


Indexed/Abstracted in: e-psyche, EMBASE, PubMed/MEDLINE, Neuroscience Citation Index, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,522


eTOC

 

Journal of Neurosurgical Sciences 2017 Nov 20

DOI: 10.23736/S0390-5616.17.04077-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Primary gliosarcoma: epidemiology, clinical presentation, management and survival

Ruichong MA, Delia-Marina ALEXE, Davide BOERIS, Erlick PEREIRA

Department of Neurosurgery, Oxford University Hospitals, Oxford, UK


PDF  


Gliosarcomas are malignant tumours of the central nervous system. As glioblastomas (GBM), they are treated in a similar fashion. However there is growing evidence to suggest that they may be a separate entity. Due to the rarity of primary gliosarcomas (PGS)Here we publish single centre data over a 14-year period, comprising possibly one of the biggest case series in the literature to our knowledge. The mean age at presentation was 59 years with male preponderance (1.75:1). The most common presenting symptoms were balance and mobility issues (61%), followed by headaches (50%) and visual problems (39%). Tumours were most likely to involve the frontal and parietal lobes (27% and 21% respectively). Patients under 50 had a significant survival advantage (50% versus 32%). All patients had surgery, 79% had adjuvant radiotherapy, with a further 21% also receiving chemotherapy. Median survival from surgery of patients diagnosed with PGS was 6.6 months. Median and one-year survival were significantly better for patients who received radiotherapy (14 months; 46% one year survival) and improved further with combined radioand chemotherapy (30 months; 77%, one year survival). For patients of good status, adjuvant chemo-radiotherapy is warranted and should be offered as it confers a muchimproved overall survival.


KEY WORDS: Primary Gliosarcoma - Glioblastoma

top of page

Publication History

Article first published online: November 20, 2017
Manuscript accepted: November 8, 2017
Manuscript revised: November 3, 2017
Manuscript received: May 7, 2017

Cite this article as

Ma R, Alexe DM, Boeris D, Pereira E. Primary gliosarcoma: epidemiology, clinical presentation, management and survival. J Neurosurg Sci 2017 Nov 20. DOI: 10.23736/S0390-5616.17.04077-2

Corresponding author e-mail

eacp@eacp.co.uk