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JOURNAL OF NEUROSURGICAL SCIENCES

A Journal on Neurosurgery


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Journal of Neurosurgical Sciences 2017 Nov 03

DOI: 10.23736/S0390-5616.17.04230-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Current and future uses of transcranial focused ultrasound in neurosurgery

David S. HERSH, Howard M. EISENBERG

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA


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Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre- clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essential tremor, Parkinson’s disease, obsessive-compulsive disorder, depression, and neuropathic pain. Ongoing clinical trials involving patients with brain tumors, Alzheimer’s disease, or epilepsy, and pre-clinical work involving stroke and hydrocephalus have the potential to significantly expand the possible indications for transcranial FUS in the future.


KEY WORDS: Focused ultrasound - Transcranial - MRI - Ablation - Blood-brain barrier

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Publication History

Article first published online: November 03, 2017
Manuscript accepted: October 24, 2017
Manuscript received: October 4, 2017

Cite this article as

Hersh DS, Eisenberg HM. Current and future uses of transcranial focused ultrasound in neurosurgery. J Neurosurg Sci 2017 Nov 03. DOI: 10.23736/S0390-5616.17.04230-8

Corresponding author e-mail

heisenberg@smail.umaryland.edu