ORIGINAL ARTICLE   

Journal of Neurosurgical Sciences 2021 February;65(1):63-8

DOI: 10.23736/S0390-5616.18.04258-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Relationship between pineal cyst size and aqueductal CSF flow measured by phase contrast MRI

Abraham F. BEZUIDENHOUT ¹ ✉, Ekkehard M. KASPER ², Olivier BALEDENT ³, Rafael ROJAS ¹, Rafeeque A. BHADELIA ¹

¹ Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; ² Department of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, MA, USA; ³ Department of Imaging and Biophysics, Amiens-Picardy Nord University Hospital, Amiens, France

BACKGROUND: Most patients with pineal cysts referred for neurosurgical consultation have no specific symptoms or objective findings except for pineal cyst size to help in management decisions. Our purpose was to assess the relationship between pineal cyst size and aqueductal CSF flow using PC-MRI.
METHODS: Eleven adult patients with pineal cysts (>1 cm) referred for neurosurgical consultations were included. Cyst volume was calculated using 3D T1 images. Phase contrast magnetic resonance imaging (PC-MRI) in axial plane with velocity encoding of 5 cm/sec was used to quantitatively assess CSF flow through the cerebral aqueduct to determine the aqueductal stroke volume, which was then correlated to cyst size using Pearson’s correlation. Pineal cysts were grouped by size into small (6/11) and large (5/11) using the median value to compare aqueductal stroke volume using Mann-Whitney test.
RESULTS: Patients were 39±13 years (mean±SD) of age, and 10/11 (91%) were female. There was significant negative correlation between cyst volume and aqueductal stroke volume (r=0.74; P=0.009). Volume of small cysts (4954±2157 mm³) was significantly different compared to large cysts (13,752±3738 mm³; P=0.008). The aqueductal stroke volume of patients harboring large cysts 33±8 μL/cardiac cycle was significantly lower than that of patients with small cysts 96±29 μL/cardiac cycle (P=0.008).
CONCLUSIONS: Aqueductal CSF flow appears to decrease with increasing pineal cyst size. Our preliminary results provide first evidence that even in the absence of objective neurological findings or hydrocephalus; larger pineal cysts already display decreased CSF flow through the cerebral aqueduct.

KEY WORDS: Magnetic resonance imaging; Pineal gland; Central nervous system cysts; Hydrocephalus