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REVIEW  SEVERE TRAUMATIC BRAIN INJURY 

Journal of Neurosurgical Sciences 2018 October;62(5):563-73

DOI: 10.23736/S0390-5616.18.04476-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Neuroprotection in traumatic brain injury

Masoom DESAI 1 , Abhi JAIN 2

1 Division of Neurocritical Care, Program in Trauma, University of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, MD, USA; 2 Philadelphia College of Osteopathic Medicine, Philadelphlia, PA, USA


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Traumatic brain injury (TBI) has a high incidence worldwide and is associated with significant morbidity and mortality. TBI has enduring implications in several domains and limits overall quality of life even in the survivors. Assessment of failures of different strategies attempted at improving outcomes in traumatic brain injury is required. Several neuroprotective strategies have been studied to limit the morbidity and mortality associated with TBI. Various approaches, both pharmacologic and surgical, have been tried. In this article, we will review the epidemiology of TBI, the impact of secondary brain injury on outcomes and different strategies in traumatic brain injury. Furthermore, discussion into failure of different strategies and necessary future approach will be discussed. TBI remains a challenging condition to intervene on due to its heterogeneity. Future work should incorporate a multi-disciplinary as well as multi-center approach to target specific subset of patient population.


KEY WORDS: Brain injuries, traumatic - Neuroprotection - Morbidity - Mortality

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