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Journal of Neurosurgical Sciences 2014 September;58(3):145-9

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor

Dela Peña I. 1, Sanberg P. R. 1, Acosta S. 1, Tajiri N. 1, Lin S. Z. 2, Borlongan C. V. 1

1 Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA; 2 Center for Neuropsychiatry, China Medical University and Hospital, No.2 Yude Road, Taichung, Taiwan, Republic of China


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Traumatic brain injury (TBI), often called the signature wound of Iraq and Afghanistan wars, is characterized by a progressive histopathology and long-lasting behavioral deficits. Treatment options for TBI are limited and patients are usually relegated to rehabilitation therapy and a handful of experimental treatments. Stem cell-based therapies offer alternative treatment regimens for TBI, and have been intended to target the delayed therapeutic window post-TBI, in order to promote “neuroregeneration,” in lieu of “neuroprotection” which can be accomplished during acute TBI phase. However, these interventions may require adjunctive pharmacological treatments especially when aging is considered as a comorbidity factor for post-TBI health outcomes. Here, we put forward the concept that a combination therapy of human umbilical cord blood cell (hUCB) and granulocyte-colony stimulating factor (G-CSF) attenuates neuroinflammation in TBI, in view of the safety and efficacy profiles of hUCB and G-CSF, their respective mechanisms of action, and efficacy of hUCB+G-CSF combination therapy in TBI animal models. Further investigations on the neuroinflammatory pathway as a key pathological hallmark in acute and chronic TBI and also as a major therapeutic target of hUCB+G-CSF are warranted in order to optimize the translation of this combination therapy in the clinic.

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