ANDROLOGY 2013 

Minerva Urologica e Nefrologica 2013 June;65(2):133-55

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

Testicular germ cell tumors. Current concepts and management strategies

Cost N. G. ✉

Division of Urology, University of Cincinnati College of Medicine and the Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

Testicular germ cell tumors (T-GCTs) are the most common solid tumor in adolescent and young adult men. Due to the success of multidisciplinary management, the prognosis of all stages of T-GCT is quite good. The development of complimentary therapeutic strategies including modern cytotoxic chemotherapy regimens, appropriate utilization of radiotherapy, and timely surgical resection has made T-GCTs the model of a “curative” malignancy. Herein we review the background, epidemiology, and genetics of the disease, as well as an approach to its diagnosis and staging, including rationale for managing T-GCT in its various stages. In summary, while some areas in T-GCT care are debated, the vast majority of patients should be approached in a standardized manner which ensures optimal oncologic outcomes and minimal therapeutic morbidity.