CASE REPORTS   

Minerva Urologica e Nefrologica 2007 December;59(4):451-4

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

Synchronous primary triple neoplasia (renal cell carcinoma and prostate cancer in combination with thyroid neoplasm). Report of an unusual case

Rai R. S. ¹, Deb P. ², Rai R. ³, Gupta E. ³, Panayach J. S. ⁴

¹ Department of Urology Military Hospital, Udhampur Jammu and Kashmir, India 2 Department of Pathology Military Hospital, Udhampur Jammu and Kashmir, India 3 Department of Medicine Government Medical College, Chandigarh, India 4 Department of Pathology Military Hospital, Chandimandir, India

We report a very rare case of triple primary neoplasia synchronously originating in the prostate, kidney and thyroid, in a 79-year-old male who presented with hematuria and continuous pain at the right hip. Examination revealed an enlarged nodular thyroid, while digital rectal examination showed prostatic enlargement with elevated PSA (16.7 ng/mL). Plain radiography showed an osteolytic lesion in the right ischium. Ultrasonography and CT scan of left kidney suggested renal cell carcinoma (RCC), which was subsequently confirmed on histopathology of the left radical nephrectomy specimen. Biopsies from prostate showed adenocarcinoma, along with deposits in ischial biopsy. Fine needle aspiration cytology (FNAC) of neck swellings suggested deposits from follicular cell carcinoma thyroid, which was subsequently confirmed by histopathology of the near-total thyroidectomy specimen. Currently, patient is on regular follow-up since the past 24 months.