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Minerva Urologica e Nefrologica 2000 June;52(2):67-72

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: Italian

Uremic blood coagulation. The role of thrombin

Camici M., Sagripanti A.

Università degli Studi - Pisa Dipartimento di Medicina Interna *Ospedale S. Chiara - Pisa

The recent observation of increased thrombinogenesis in chronic renal failure suggest a pathogenetic role of thrombin in hemorrhagic diathesis of chronic renal failure that may link two paradoxical aspects of this diathesis: hemorrhage and thrombosis. Not only: the accelerated atherosclerosis in uremic patient is also underlined. The possibility of thrombin therapeutic inhibition is then discussed.