Home > Journals > Minerva Urologica e Nefrologica > Past Issues > Articles online first > Minerva Urologica e Nefrologica 2017 Nov 21

CURRENT ISSUE
 

ARTICLE TOOLS

Publication history
Reprints
Cite this article as

MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,984


eTOC

 

Minerva Urologica e Nefrologica 2017 Nov 21

DOI: 10.23736/S0393-2249.17.03009-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Intravenous Dextran 70 infusion has protective effects on ischemia reperfusion injury of kidney: an experimental study

Atilla SEMERCIOZ 1, Mustafa Z. TEMIZ 1 , Ipek ERBARUT 2, Ugur IZOL 2, Serdar AYKAN 1, Murat TUKEN 1, Engin KANDIRALI 1

1 Department of Urology, Bagcilar Training and Research Hospital, Merkez Mh. Mimar Sinan Caddesi, Istanbul, Turkey; 2 Department of Clinical Pathology, Bagcilar Training and Research Hospital, Merkez Mh. Mimar Sinan Caddesi, Istanbul, Turkey


PDF  


BACKGROUND: Renal ischemia-reperfusion (IR) leads to alterations of tubular epithelial cells, interstitial microvasculopathy and endothelial cell dysfunction in peritubular capillaries. Although dextrans have deteriorative effects on healthy kidney, their favorable effects on post-ischemic microvascular disturbances have been demonstrated. Therefore, we aimed to investigate in vivo effects of systemic Dextran 70 administration in kidney tissue with ischemia-reperfusion injury.
METHODS: Twenty-one rats were allocated as sham, IR and IR+ Dextran 70 treatment groups. Perirenal dissection without ischemia-reperfusion injury was performed with 0.9 NaCl solution infusions in the sham group. The left renal ischemia-reperfusion injury model was induced with % 0.9 NaCl and Dextran 70 solutions infusion were maintained in the IR and IR+ Dextran 70 treatment groups, respectively. At the end of the experimental procedures, histopathologic findings, serum creatinine and blood urea nitrogen levels, 24 hour urinary volumes, urinary albumin, KIM-1and IL-18 levels, tissue MDA and SOD levels were compared between the groups.
RESULTS: We determined slightly reduction of the histopathologic structural changes and significant reduced levels of the albuminuria and KIM-1 in the IR +Dextran 70 treatment group (p=0.03 and p=0.02, respectively). Higher 24 hour urine out put and free radical scavenger SOD levels were also detected with Dextran 70 treatment (p=0.0 and p=0.03, respectively).
CONCLUSIONS: Intravenous Dextran 70 infusion has some substantial protective effects against the ischemic injury of kidney.


KEY WORDS: Dextran 70 - Kidney - Ischemia-reperfusion injury

top of page

Publication History

Article first published online: November 21, 2017
Manuscript accepted: November 8, 2017
Manuscript revised: September 22, 2017
Manuscript received: July 14, 2017

Cite this article as

Semercioz A, Temiz MZ, Erbarut I, Izol U, Aykan S, Tuken M, et al. Intravenous Dextran 70 infusion has protective effects on ischemia reperfusion injury of kidney: an experimental study. Minerva Urol Nefrol 2017 Nov 21. DOI: 10.23736/S0393-2249.17.03009-0

Corresponding author e-mail

dr_mustafazafertemiz@hotmail.com