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MINERVA UROLOGICA E NEFROLOGICA

A Journal on Nephrology and Urology


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Minerva Urologica e Nefrologica 2018 February;70(1):42-52

DOI: 10.23736/S0393-2249.17.02953-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Should radical prostatectomy be encouraged at any age? A critical non-systematic review

Fabio ZATTONI 1, Francesco MONTEBELLI 2, Marta ROSSANESE 3, Alessandro CRESTANI 1, Gianluca GIANNARINI 1, Vincenzo FICARRA 4

1 Unit of Urology, Academic Medical Center Hospital “Santa Maria della Misericordia”, Udine, Italy; 2 Unit of Urology, Department of Oncologic, Surgical and Gastrointestinal Sciences, University of Padua, Padua, Italy; 3 Unit of Urology, Department of Surgery, University of Catania, Catania, Italy; 4 Unit of Urology, Department of Human and Pediatric Pathology “Gaetano Barresi”, University of Messina, Messina, Italy


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Elderly men are likely to be diagnosed with clinically localized prostate cancer, however only few studies have assessed the appropriate treatment in such patients. Radical prostatectomy is one valid alternative. Perioperative outcomes, functional outcomes and oncological outcomes have to be carefully discussed in patient counselling. Fewer perioperative complications, lower perioperative mortality, and shorter hospitalization times have been reported for patients undergoing radical prostatectomy by high-volume surgeons at high-volume centers. Although elderly patients are more likely to be preoperatively incontinent, and increasing age impacts negatively on continence recovery, long-term urinary continence rates have been reported to be satisfactorily high also in older patients. Potency should not be considered as a relevant outcome, since many elderly patients already suffer from longstanding erectile dysfunction and advanced age itself is associated with low chances of recovery. Although some inter-study variability exists in different oncological outcomes measured, most studies are consistent in showing no different cancer-specific survival rates between younger and older patients, thus implying that even elderly patients may benefit from radical treatment. Biological rather than chronological age should be used to base the decision as to whether a patient will profit from definitive treatment. Therefore, elderly men should undergo a health assessment using validated tools before any treatment decision. Only fit and motivated individuals with a reasonable life expectancy and, above all, high-risk disease should be offered radical prostatectomy. In these patients, high-volume surgeons and minimally invasive approaches should be preferable to minimize perioperative complications.


KEY WORDS: Prostatectomy - Prostatic neoplasms - Comorbidity - Life expectancy

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Publication History

Issue published online: January 30, 2018
Article first published online: September 27, 2017
Manuscript accepted: September 26, 2017
Manuscript revised: September 5, 2017
Manuscript received: April 13, 2017

Cite this article as

Zattoni F, Montebelli F, Rossanese M, Crestani A, Giannarini G, Ficarra V. Should radical prostatectomy be encouraged at any age? A critical non-systematic review. Minerva Urol Nefrol 2018;70:42-52. DOI: 10.23736/S0393-2249.17.02953-8

Corresponding author e-mail

vficarra@unime.it