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Minerva Urologica e Nefrologica 2017 August;69(4):324-9

DOI: 10.23736/S0393-2249.16.02623-0

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Matrix metalloproteinase 9 and prostate cancer risk: a meta-analysis of 1059 participants

Fuling MA, Zhun WANG, Abdulalam ABDULARAB, Liang DAI, Yuanjie NIU, Ning JIANG

Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, China


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INTRODUCTION: Numerous studies have evaluated the association between the matrix metalloproteinase 9 (MMP-9) and prostate cancer (PCa) risk. However, these studies have yielded conflicting results.
EVIDENCE ACQUISITION: A comprehensive search was conducted through researching MEDLINE, PubMed, Web of Science, and EMBASE, and a total of 10 studies including 1059 cases were included on the basis of inclusion criteria.
EVIDENCE SYNTHESIS: A meta-analysis was performed to obtain a summary of estimated odds ratios (ORs) and 95% confidence intervals (CIs) of MMP-9 for PCa, with attention to study quality and publication bias. MMP-9 by immunohistochemistry was significantly associated with increased diagnosis of PCa (OR=7.91; 95% CI: 5.27-11.89; P<0.00001). Subgroup-analysis showed that findings did not substantially change when only Caucasians or Asians (OR=5.87; 95% CI: 3.38-10.20; P<0.00001) or (OR=11.80; 95% CI: 6.60-21.08; P<0.00001) were considered. There was also no significant publication bias observed.
CONCLUSIONS: Our findings provide further evidence that the expression of MMP-9 contribute to PCa risk. MMP-9 protein overexpression was found in prostate cancers, low expression in any of the normal tissues or in benign prostatic tissue. MMP-9 is potentially an important prostate tumor marker.


KEY WORDS: Matrix metalloproteinase 9 - Prostatic neoplasms - Meta-analysis - Diagnosis - Biomarkers

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