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Minerva Urologica e Nefrologica 2008 June;60(2):123-35

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: Italian

Spontaneous regression of lung metastases from renal cell carcinoma: the importance of immunogenetic factors and a review of the literature

Crisci A. 1, Corsale I. 2, Abrami F. 2, Politi L. 2, Andreani M. 2, Borgianni S. 2, Barale D. 2, Porfirio B. 3

1 Dipartimento di Area Critica Medico Chirurgica Urologia I Università degli Studi di Firenze, Firenze, Italia 2 Dipartimento di Chirurgia Toracica Università degli Studi di Firenze, Firenze, Italia 3 Dipartimento di Fisiopatologia Clinica Cattedra di Genetica Medica Università degli Studi di Firenze, Italia


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Spontaneous regression of renal cell cancer (RCC) metastases most frequently occurs after nephrectomy, since reducing target size makes possible a more effective immune response. RCC is immunotherapy-sensitive, as are RCC metastases, especially metastases to the lungs (organs are rich in immune cells and continually exposed to antigens), which have an antigenic effect. Immunotherapy could be perfected if a renal antigen that could be incorporated into a vaccine were identified. This would have played an important role in treatment and follow-up. Vaccine therapy for RCC is no longer far out of reach. The characteristics of RCC make it a fertile field for the study of prometastatic and endogenous antiangiogenic factors.

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