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Minerva Urologica e Nefrologica 2004 September;56(3):279-88

Copyright © 2004 EDIZIONI MINERVA MEDICA

language: English

Cardiovascular disease in renal failure

Guerin A. P., Adda H., London G. M., Marchais S. J.

Department of Nephrology Manhes Hospital, Fleury-Merogis, France

Cardiovascular dis­ease is prev­a­lent in pa­tients ­with chron­ic kid­ney dis­ease and may ac­count for 50% of all ­deaths. Left ven­tric­u­lar hy­per­tro­phy is the ­most fre­quent car­diac al­ter­a­tion in end-­stage re­nal dis­ease (­ESRD) pa­tients. It is due to a com­bi­na­tion of he­mo­dy­nam­ic and hu­mo­ral fac­tors. Volume over­load and pres­sure over­load are re­spon­sible for ad­ap­ta­tive al­ter­a­tions of the ­heart and the ves­sels con­sid­er as a ­unique func­tion­al ­system. These al­ter­a­tions ­are ­first ben­e­fi­cial but ­their per­sis­tence ­leads to a det­ri­men­tal pro­cess, main­ly car­diac di­la­tion and fail­ure. Treatment of the he­mo­dy­nam­ic over­load ­could par­tial­ly sta­bi­lize or re­verse ­this ev­o­lu­tion.