Home > Journals > Minerva Urologica e Nefrologica > Past Issues > Minerva Urologica e Nefrologica 2003 September;55(3) > Minerva Urologica e Nefrologica 2003 September;55(3):173-83

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

REVIEWS   

Minerva Urologica e Nefrologica 2003 September;55(3):173-83

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: Italian

Inheritance in neoplastic urogenital pathology

Alberti C.

Cattedra di Urologia 1 Dipartimento di Discipline Medico-Chirurgiche Università degli Studi di Torino, Torino


PDF


In the course of the last decades, dramatic advances in the field of molecular biology have greatly increased our knowledges regarding the chromosomal aberrations associated with both hereditary and sporadic tumours. The development of new techniques (RELF, FISH, CGH, cDNA array analysis and functional oncogenetics, etc.) has provided powerful new tools for identification of onco- and oncosuppressor predisposing-genes. The most logical consequence of genetic research is the gene-therapy by directing treatment to the site of the chromosomal defect. The implementation of gene-directed technologies (gene-replacement or augmentation, antisense, interfering small -RNAs, etc.) into clinical practice stands as a model of translational research from laboratory to bedside. Prevention and therapy may be widely influenced by the experience of these techniques. On the other hand, some chemoprevention trials are carried out in subjects with hereditary risk for prostate cancer. The paper aims to outline the advances of genetics in urogenital hereditary tumours on the basis of a review of the literature in this field.

top of page