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Minerva Urologica e Nefrologica 2000 December;52(4):201-6

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: Italian

Role of nitric oxide in the genitourinary system. Physiology and pathology

Sciarra A., Voria G., Gentile V., Pastore A. L., Di Chiro C., Loreto A., Di Silverio F.

Università degli Studi «La Sapienza» - Roma Dipartimento di Urologia «U. Bracci»


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A review has been made on the role of nitric oxide in the physiology and pathophysiology of penis, bladder, prostate and the nervous structures involved in the urinary control. NO is an essential mediator in penile erection and his action can be modulated by sildenafil. Nitric oxide could be involved in bladder detrusor relaxation and in the development of interstitial cystitis. Little is known about the role of nitric oxide in the physiology and pathophysiology of the prostate: this molecule is released by the epithelial and stromal cells of the prostate, and by the prostatic nerves. Actually some studies hypothesize a role played by nitric oxide in benign prostatic hyperplasia development.

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