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Minerva Surgery 2021 Apr 23

DOI: 10.23736/S2724-5691.21.08654-5


language: English

Correlation analysis of pleural effusion and lung infection after liver transplantation

Chuanshen XU, Weina ZHANG, Xin WANG, Zhiqiang LI, Ge GUAN, Shuxian WANG, Ning FAN, Yuan GUO, Wei RAO, Jianhong WANG, Taohua ZHENG, Yunjin ZANG

Organ Transplantation Center, the Affiliated Hospital of Qingdao University, Qingdao City, Shandong, China


BACKGROUND: To probe the association of pleural effusion with lung infection of patients with liver transplantation, and to provide a theoretical foundation for preventing, diagnosing and remedying pulmonary complications after liver transplantation.
METHODS: Our team harvested clinical data of patients undergoing orthotopic allogeneic liver transplantation complicated with pleural effusion after surgery in our institution from May 2018 to July 2019. Based on whether puncture drainage was needed, patients were allocated to either control group or observation group. The differences in pleural effusion depth, lung function, lung infection, serum inflammatory factor levels and 6-month survival before and after surgery were compared. Finally, ROC curves were constructed for dissecting the correlation of pleural effusion with lung infection.
RESULTS: On day 3 after surgery, (1) pleural effusion depth of the observation group was (5.70±1.20) cm, which was saliently greater than that of control group (P<0.05); (2) in comparison to control group, lung function indexes FVC, FEV1.0, MVV and PaO2 of observation group declined (all P<0.05); (3) sputum culture evinced that the lung infection rates of control group and observation group were 17.24% and 71.70% separately, and observation group harbored brilliantly higher infection rate (P<0.05); (4) in comparison to control group, IL-6, IL-8, TNF-α contents in observation group augmented (P<0.05); (5) AUC of pleural effusion depth and lung infection was 0.849, 0.805 and 0.853 separately on days 1, 2, 3 after surgery.
CONCLUSIONS: A positive correlation is existed between pleural effusion and lung infection after liver transplantation. When patients have persistent pleural effusion, the incidence of lung infection should be prevented and reduced.

KEY WORDS: Liver transplantation; Pleural effusion; Lung infection

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