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ORIGINAL ARTICLE  CLINICAL APPLICATION OF INDOCYANINE GREEN IN LIVER SURGERY 

Minerva Surgery 2021 June;76(3):211-9

DOI: 10.23736/S2724-5691.21.08597-7

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Intraoperative guidance using ICG fluorescence imaging system for safe and precise laparoscopic liver resection

Yuichiro OTSUKA , Yu MATSUMOTO, Yuko ITO, Rei OKADA, Tetsuya MAEDA, Jun ISHII, Yoji KAJIWARA, Kazunori OKUBO, Kimihiko FUNAHASHI, Hironori KANEKO

Division of General and Gastroenterological Surgery (Omori), Department of Surgery, Toho University Faculty of Medicine, Tokyo, Japan



BACKGROUND: Laparoscopic liver resection (LLR) has been spread as minimally invasive surgery for liver disease. Advances in surgical technique and devices enabled us to perform various procedures of LLR. Indocyanine green (ICG) fluorescence imaging has been suggested as useful tool to identify liver tumors, anatomical territory of liver parenchyma, and cholangiography in open liver surgery. Due to recent development, this technology can be applied in LLR. we describe safe and effective using of the ICG fluorescence imaging during LLR.
METHODS: From September 2013 to August 2019, 34 patients were performed LLR using a total of 46 procedures by ICG fluorescence imaging system for purposes including identification of anatomic domain of the liver in 12 LLRs, detection of liver tumors in 30 nodules, or intraoperative cholangiography in 4 LLRs.
RESULTS: During the detection of liver tumors, 25 nodules in 30 malignant to benign tumors were positively detected (83.3%). Although there has been no publication regarding information on ICG fluorescence imaging of low grade malignant or benign tumors, we found positive emission in focal nodular hyperplasia, an angiomyolipoma, and an intraductal papillary neoplasm of the bile duct. The identification of anatomic domain in the liver was successful in all 12 LLRs with negative and positive staining techniques. In the intraoperative cholangiography, all 4 tests were successfully performed. One of 4 patients were found to have biliary leakage which was repaired intraoperatively.
CONCLUSIONS: The ICG fluorescence imaging could be useful in safe and precise performance of LLR.


KEY WORDS: Laparoscopy; Liver; Indocyanine green; Optimal imaging; Hepatectomy; Spectroscopy, near-infrared

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