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Minerva Stomatologica 2020 Jul 21

DOI: 10.23736/S0026-4970.20.04389-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Direct oral anticoagulants in oral surgery: a prospective cohort

Amanda ROCHA 1, Sicilia OLIVEIRA 1, Alessandra SOUZA 1, Denise TRAVASSOS 2, Lucas G. ABREU 3, Daniel RIBEIRO 4, Tarcilia SILVA 1

1 Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; 2 Department of Community and Preventive Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; 3 Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; 4 Department of Hematology, Faculty of Medicine, Universidade Federal de Minas Gerais, Minas Gerais, Brazil


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BACKGROUND: Quantitative assessment of bleeding in dental extractions is rarely reported in the literature. The assessment of bleeding might provide additional evidence to predict and minimize postoperative outcomes. The aim of this study was to evaluate the pattern of bleeding in individuals taking direct oral anticoagulants (DOACs) submitted to dental extractions.
METHODS: Intraoperative bleeding was evaluated by using total collected bleeding corrected by absorbance reading (dental bleeding score). To monitoring bleeding episodes from the day of surgery, this cohort was followed up until the 11 seventh postoperative day.
RESULTS: Forty-five procedures were performed in three comparative groups, patients under DOACs, individuals taking vitamin K antagonists (VKAs) and without anticoagulant therapy. No bleeding events were observed in procedures carried out in individuals of the DOAC group. Additional hemostatic measures were required in two procedures in the VKA group and one in the non-anticoagulated group. The dental bleeding scores obtained for the DOAC and VKA groups were similar.
CONCLUSIONS: Our data suggest that the DOAC therapy did not result in increased bleeding outcomes in this sample.


KEY WORDS: Anticoagulants; Oral surgical procedures; Tooth extraction; Postoperative hemorrhage

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