Home > Journals > Minerva Stomatologica > Past Issues > Minerva Stomatologica 2018 February;67(1) > Minerva Stomatologica 2018 February;67(1):20-5



Publication history
Cite this article as


A Journal on Dentistry and Maxillofacial Surgery

Official Journal of the Italian Society of Odontostomatology and Maxillofacial Surgery
Indexed/Abstracted in: CAB, EMBASE, Index to Dental Literature, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Stomatologica 2018 February;67(1):20-5

DOI: 10.23736/S0026-4970.17.04086-9


language: English

Molar incisor hypomineralization treatment with casein phosphopeptide and amorphous calcium phosphate in children

Marco PASINI 1, Maria R. GIUCA 1, Martina SCATENA 1, Roberto GATTO 2, Silvia CARUSO 2

1 Unit of Pediatric Dentistry, Dental Clinic, Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy; 2 Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy


BACKGROUND: The purpose of this study was to evaluate the sensitivity of teeth with MIH in children before and after the use of a tooth mousse containing casein phosphopeptide and amorphous calcium phosphate (CPP-ACP).
METHODS: Forty patients, both males and females, aged from 8 to 13 years old that had a molar with MIH hypersensitivity were included in this study. In the test group (20 subjects), a tooth mousse with CPP-ACP was used while fluoride toothpaste was used in the control group. Dental sensitivity to mechanical and thermal stimuli was evaluated before (T0) and 120 days after the beginning of the treatment (T1).
RESULTS: In the test group, the thermal sensitivity decreased significantly (P<0.05) from T0 to T1 (2.4±0.6 to 1.1±0.4) while in the control group resulted very similar (from 2.3±0.5 to 2.2±0.4). Similarly, mechanical sensitivity decreased significantly (P<0.05) from 7.8±1 to 3.8±0.6 while in the control group decreased not significantly (from 7.5±1.3 to 7.2±0.8). No significant difference (P>0.05) was observed by comparing males with females.
CONCLUSIONS: The use of the remineralizing agent containing CPP-ACP resulted in a significant improvement in dental sensitivity in patients with MIH.

KEY WORDS: Hypomineralization - Dental enamel - Children - Therapy

top of page

Publication History

Issue published online: December 7, 2017
Article first published online: October 3, 2017
Manuscript accepted: September 26, 2017
Manuscript revised: August 31, 2017
Manuscript received: May 25, 2017

Cite this article as

Pasini M, Giuca MR, Scatena M, Gatto R, Caruso S. Molar incisor hypomineralization treatment with casein phosphopeptide and amorphous calcium phosphate in children. Minerva Stomatol 2018;67:20-5. DOI: 10.23736/S0026-4970.17.04086-9

Corresponding author e-mail