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Minerva Stomatologica 2013 September;62(9):343-8


language: English

Brown tumor of hyperparathyroidism involving craniomaxillofacial region: a rare case report and literature review

Chowdhury S. 1, Aggarwal A. 2, Mittal N. 3, Shah A. 3

1 Department of Oral and Maxillofacial Surgery Institute of Dental Science, Bareilly Uttar Pradesh, India; 2 Department of Oral Medicine and Radiology Institute of Dental Science, Bareilly Uttar Pradesh, India; 3 Consultant Oral and Maxillofacial Surgeon Chandigarh, India; 4 Department of Oral and Maxillofacial Surgery Raja Rajeswari Dental College and Hospital Bangalore, India


Central giant cell granuloma (CGCG) is a benign, non-odontogenic bone lesion of jaw. The condition is relatively infrequent and affects mainly children and young adults with a certain predominance among females and exhibits variable aggressiveness. Giant cell lesion associated with hyperparathyroidism is known as Brown tumor. Brown tumor is one of the bony complications of hyperparathyroidism. It is a giant cell granuloma which occurs in osteitis fibrosis cystica. It represents the terminal stage of the bone remodelling processes occurring as a result of peritrabecular fibrosis and osteoclastic activity. The mandible is the predominantly affected site in the maxillofacial area. Maxillary involvement is rare. The incidence of Brown tumor associated with hyperparathyroidism is rare (0.1%). Here, an extremely rare case of a 20 year old female patient with Brown tumor in her maxilla and mandible associated with primary hyperparathyroidism was presented. A thorough diagnostic work up showed presence of tumor mass in mandible and maxilla and elevated serum alkaline phosphatase and parathormone level and the patient was treated for both hyperparathyroidism and Brown tumor were discussed.
The importance of different radiological evaluation methods and the consultation between the oral and maxillofacial surgeons, dentists, endocrinologists and radiologists were emphasized.

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