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Minerva Stomatologica 2012 November-December;61(11-12):509-17

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: English, Italian

Dentinogenic ghost cell tumor: histopathology and clinical aspects in pediatric age

Ramaglia L. 1, Esposito D. 1, Bruno M. P. 1, Siano M. 2

1 Department of Odontostomatological and Maxillofacial Sciences, “Federico II” University of Naples, Naples, Italy; 2 Department of Biomorphological and Functional Sciences, “Federico II” University of Naples, Naples, Italy


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The dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor histologically characterized by islands of odontogenic epithelium with the presence of ghost cells and dysplastic dentin at different stages of calcification. Central DGCT may have a locally invasive behavior with variable rates of recurrence. We report the distinguishing case of two central DGCTs localized bilaterally in the maxilla of a female patient in pediatric age, initially detected as complex odontomas associated with impacted teeth and surgically removed by means of piezoelectric bone surgery. After the removal of odontogenic lesions with the presence of calcified tissues, histopathological examination allows the identification of lesions that, although uncommon, show the potential of local invasiveness requiring an adequate follow-up in order to observe any sign of disease recurrence.

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