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Minerva Stomatologica 2010 October;59(10):579-81

Copyright © 2010 EDIZIONI MINERVA MEDICA

Orofacial granulomatosis of the lip: a report of 2 cases with histological and immunohistochemical analyses and intralesional corticotherapy

Martini M. Z., Galletta V. C., Pereira É. M., De Sousa S. C. O. M., Lemos C. A., Migliari D. A.

1 Department of Oral Diagnosis, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil 2 Department of Oral Pathology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.


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Orofacial granulomatosis is a generic term applied to manifestations of several diseases including sarcoidosis, Crohn’s disease, Melkersson-Rosenthal syndrome, cheilitis granulomatosa of Miescher, tuberculosis and foreign-body reactions. What bonds these diseases together is the presence of noncaseating granulomas. A typical clinical manifestation of orofacial granulomatosis is recurrent labial swellings that eventually persist. This article describes 2 cases of OG diagnosed with the aid of immunohistochemical analysis and successfully treated with intralesional steroids.

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