Home > Journals > Minerva Stomatologica > Past Issues > Minerva Stomatologica 2008 October;57(10) > Minerva Stomatologica 2008 October;57(10):505-9

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints

 

ORIGINAL ARTICLES   

Minerva Stomatologica 2008 October;57(10):505-9

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Sex, age and ABO blood groups in chemotherapy-induced oropharyngeal mucositis

Otmani N. 1, Alami R. 2, Soulaymani A. 3, El Mokhtari A. 3, Khattab M. 1

1 Unit of Pediatric Hemato-Oncology Children Hospital, Rabat, Morocco 2 National Blood Transfusion Center, Rabat, Morocco 3 Laboratory of Genetics and Biometry Ibn Tofaïl University, Kénitra, Morocco


PDF


Aim. The contribution of host genetic factors in oropharyngeal mucositis is not fully understood. Therefore, we conducted this study to determine possible associations of age, sex, underlying disease, type of chemotherapy and ABO blood group antigens with the risk of chemotherapy-induced oropharyngeal mucositis.
Methods. A total of 641 patients (395 boys and 246 girls; mean age 6.82±4.08 years) treated by standard chemotherapy for different type of malignancies were enrolled in the study. Mucositis was scored using the WHO scale.
Results. Oropharyngeal mucositis was found in 65.4% of our population. Patients with hematological malignancies (RR=1.87; 95% CI 1.33-2.67; P<0.0001) and under antimetabolities drugs (RR=1.88; 95% CI 1.33-2.63; P<0.0001) were associated with increased risk of oropharyngeal mucositis. Also, patients with blood group O were at higher risk (RR=2.86; 95% CI 2.03-4.02; P<0.0001) compared to patients with blood type A (RR= 0.47; 95% CI 0.33-0.66; P<0.0001) and blood type B (RR=0.59; 95% CI 0.38-0.91; P= 0.01). No relationship was found between oropharyngeal mucositis and age or sex.
Conclusion. To our knowledge this is the first report demonstrating an association between ABO blood group and oropharyngeal mucositis. Further investigations are needed for a better understanding of this relationship.

top of page