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Minerva Stomatologica 2008 September;57(9):453-7

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

A rare case of sclerosing mucoepidermoid carcinoma arising in minor salivary glands with immunohistochemical evaluation

Aguiar M. C. F. 1, Bernardes V. F. 1, Cardoso S. V. 2, Barbosa A. A. 3, Mesquita R. A. 1, Carmo M. A. V. 1

1 Department of Oral Surgery, Oraò Medicine and Oral Pathology, School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte, Brazil 2 Department of Oral and General Pathology School of Dentistry Universidade Federal de Uberlândia Uberlândia, Brazil 3 Department of Surgery, School of Medicine Universidade Federal de Minas Gerais Belo Horizonte, Brazil


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Mucoepidermoid carcinomas (MECs) are the most common malignancy of the salivary glands demonstrating a wide range of histologic variants and behavior. However, the sclerosing mucoepidermoid carcinoma (SMEC), a morphologic variant of this tumor is extremely rare and has been described almost exclusively in the major glands. The prominent sclerosis observed may obscure its typical morphological feature resulting in a diagnostic challenge. We describe herein a case of SMEC in a 43-year-old-woman, occurring in the minor salivary glands of palate. To our knowledge only 13 cases have been reported until this moment, being only 2 in minor salivary glands. We also performed the immunohistochemical evaluation of c-erbB-2 and Ki-67, searching for an association with the histopathological findings and behavior.

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