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Minerva Stomatologica 2008 May;57(5):215-25


language: English, Italian

Influence of amine fluoride/stannous fluoride mouthwashes with and without chlorhexidine on secretion of proinflammatory molecules by peri-implant crevicular fluid cells

Di Carlo F. 1, Quaranta A. 1, Di Alberti L. 2, Ronconi L. F. 1, Quaranta M. 1, Piattelli A. 2

1 Department of Prosthodontics Dental School Rome University La Sapienza, Rome, Italy 2 University Gabriele D’Annunzio, Chieti, Italy


Aim. Patients with dental implants need optimal plaque control. Peri-implantitis is an inflammation of soft and hard tissues around implants characterized by bone loss mediated by proinflammatory molecules such as IL-1β, PGE2, vascular endothelial growth factor (VEGF). The aim of this study was to evaluate the influence of amine fluoride/stannous fluoride (AmF-SnF2) vs chlorhexidine 0.12% (CHX) combined with Am-SnF2 on IL-1β, PGE2 and EGF secretion by cells of crevicular peri-implant fluid.
Methods. Thirty patients with dental implants were included in this study. The test group used AmF-SnF2 rinsing for 14 days, the control group used CHX rinsing during the first 7 days and AmF-SnF2 during the following 7 days. Crevicular samples were collected using filter paper strips and assayed for level of IL-1β, PGE2 and VEGF with ELISA test. Data were analyzed with paired and unpaired t test.
Results. IL-1β, VEGF and PGE2 levels were significantly lower in test compared to control group. Comparing first with second week of treatment, a greater decrease of IL-1β and VEGF was evident in sample group during the second week. There was a lower decrease of IL-1β and VEGF during the entire treatment in control group. Differences of PGE2 levels after 7 days in both the groups were not significant while there was a significant difference during the second week.
Conclusion. The following data suggest that the use of AmF-SnF2 could decrease the production of IL-1β, PGE2 and VEGF by inflammatory cells.AmF-SnF2 could be an alternative to CHX mouth rinses in plaque control of patients with implants.

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