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Minerva Stomatologica 1999 December;48(12):567-76

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: English, Italian

Bioactivity of chitosan in dentistry. Preliminary data on chitosan-based cements

Mattioli Belmonte M., De Benedittis A., Mongiorgi R., Gandolfi M. G., Giardino R., Biagini G., Valdrè G., Muzzarelli RAA, Prati C., Dolci G.


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Background. The chemical association of chitosan with inorganic salts, such as calcium phosphate, finds a promising application in dentistry as room-temperature self-hardening cement. We present the physical, chemical and crystallographic characterization of newly-developed cements made of 1) calcium-phosphate and a chitosan gel obtained by acetic acid treatment, and 2) calcium phosphate and a chitosan gel obtained by ascorbic acid treatment. Both cements are self-hardening at room temperature.
Methods. The cements were characterized by X-ray diffractography, scanning electron microscopy and fluorine-selective electrode analysis.
Results. The chitosan-hydroxyapatite cements had hardness comparable to spongy bone and above that of PMMA.
Conclusions. The cements are promising for application in endodontics and restorative dentistry.

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