CASE REPORT   

Minerva Respiratory Medicine 2022 September;61(3):146-51

DOI: 10.23736/S2784-8477.21.01961-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Fetal inflammatory response syndrome and postnatal multi-system inflammatory syndrome in COVID-19-positive neonates

Meenakshi S. KUSHWAH ✉, Arunkrishnan BALARAVI, Lakshmi VENUGOPALAN, Sreekanth RAMASHENOY, Anita CHRISBINA, Monisha PRABHAKARN, Sumaiya ALAUDDIN, Munmun SAHNEY, Manoj K. DEENADAYALAN, Prakash PETCHIMUTHU

Department of Neonatology and Pediatrics, Dr. Mehta’s Multispeciality Hospital, Chennai, India

Increasing incidences of COVID-19 in pregnant women, and lack of data regarding vertical transmission and extent of disease in newborns, has raised a concern towards it. The fetal inflammatory response syndrome (FIRS) and multisystem inflammatory syndrome in neonates (MIS-N) is also not a well-known entity till now. This case report of two newborns is an effort to describe the different clinical scenarios of COVID-19 and its response to the treatment. The first case suggests the possible in utero transmission which is a rare mode of infection as evident from previous data and the inflammatory response, getting treated by the use of immunotherapy and antivirals. The second case suggest the horizontal transmission acquired postnatally and the severity of multisystem inflammatory syndrome in neonate which could not be revived in spite all the efforts in treatment.

KEY WORDS: Systemic inflammatory response syndrome; Child; Fetus; COVID-19; Vertical infectious disease transmission; Newborn infant