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Minerva Respiratory Medicine 2022 June;61(2):71-9

DOI: 10.23736/S2784-8477.21.01926-X

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

The relationship between PM2.5 and inflammation biomarkers in mice: a systematic review and meta-analysis

Fangxiu LIU 1, Jiangwei YANG 2, Hechuan TIAN 3, Weiqiang ZHANG 4, Huirong LIU 1

1 Department of Respiration Medicine, The Baoding Forth Central Hospital of Hebei Province, Baoding, China; 2 Department of Psychology, The TongDe Hospital of Zhejiang Province, Hangzhou, China; 3 Department of Oncology, Longhua Hospital, Shanghai, China; 4 Department of Rehabilitation, Kunming Municipal TCM Hospital, Kunming, China



INTRODUCTION: Numerous studies have reported PM2.5 effects on lung and inflammation activation in mice with different models to treat mice. A proper mice model plays a key role in saving experimental time and cost. Nonetheless, the systematic review about this has not existed.
EVIDENCE ACQUISITON: Systematic searches were conducted in four common English and Chinese electronic databases (i.e., PubMed, Embase, Web of Science, Clinical Trial, CNKI, VIP, Wan Fang, Chinese BioMedical). A meta-analysis including 19 studies was performed using R software to estimate the relationship between PM2.5 and inflammation markers and investigate the effect of modeling method on inflammation markers. Publication bias and heterogeneity of samples were tested using a funnel plot. Studies were analyzed using either a random-effect model or a fixed-effect model.
EVIDENCE SYNTHESIS: The search yielded 19 studies suitable for meta-analysis during the period from their initiation to September 1st, 2020. PM2.5 could increase IL-6, TNF-α, IL-1β, IL-4, and IL-8 levels in mice suffering PM2.5. Compared with inhalation group (SMD=2.16, 95% CI: 0.86-3.46), there was a higher level of IL-6 in serum in instillation group (SMD=3.06, 95% CI: 1.52-4.60) (P<0.01). By Contrast with inhalation group (SMD=3.80, 95% CI: 1.55-6.05), there was a lower level of TNF-α in serum in instillation group (SMD=2.78, 95% CI: 1.77-3.78) (P<0.01). Compared with inhalation group (SMD=3.06, 95% CI: 0.94-5.17), there was a higher level of IL-1β in serum in instillation group (SMD=13.98, 95% CI: -9.45-37.40) (P<0.01).
CONCLUSIONS: Intratracheal instillation of PM2.5 took a shorter time to make model of PM2.5 injury on lung and gave an alternative for investigation of different inflammation biomarkers with different model method.


KEY WORDS: Particulate matter; Inflammation; Biomarkers; Animal models; Meta-analysis

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