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Minerva Respiratory Medicine 2021 June;60(2):59-61

DOI: 10.23736/S2784-8477.21.01914-3

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

COVID-19 induced immunosuppression leading to secondary infection in a non-HIV patient

Tran T. NINH 1, Vinh DONG 2, Le Q. LOC 3, Tiffany TSAO 2, Akshay RAUT 4, Sedighe KARIMZADEH 5, Le H. MINH 3, Le H. NHI 6, Tuyet T. DAO 1, Nguyen T. ANH 1, Frank O’NEIL 2, 7, Pham N. THACH 1, Nguyen TIEN HUY 8

1 Vietnam National Hospital for Tropical Diseases, Hanoi Medical University, Hanoi, Vietnam; 2 American University of the Caribbean, Cupe Coy, Saint Maarten, the Netherlands; 3 Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 4 R.C.S.M. Government Medical College, Kolhapur, Maharashtra, India; 5 School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran; 6 Department of Radiology, Vinmec International Hospital, Ho Chi Minh City, Vietnam; 7 Nassau University Medical Center, East Meadow, New York, NY, USA; 8 School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan



Lymphopenia and immune dysfunction in COVID-19 is increasingly recognized and studied. This case report details a secondary infection following lymphopenia with CD4+ count drop in a COVID-19 patient with no history of immunosuppression or infection with HIV. The mechanism of lymphopenia, both CD4+ and CD8+ T cell count drops, in COVID-19 needs further study.


KEY WORDS: COVID-19; Immunosuppression; Lymphopenia; Coinfection; HIV

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