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Minerva Psichiatrica 2020 December;61(4):171-83

DOI: 10.23736/S0391-1772.20.02092-0


language: English

Evaluating the feasibility of the Italian version of the computerized interactive remediation of cognition training for schizophrenia (CIRCuiTS)

Caterina LA CASCIA 1 , Laura FERRARO 1, Fabio SEMINERIO 1, Alessandra SCAGLIONE 1, Giuseppe MANIACI 1, Domenica MATRANGA 2, Lucia SIDELI 1, Giuseppe COLLI 1, Crocettarachele SARTORIO 1, Filippo LA PAGLIA 1, Giada TRIPOLI 1, Rosa LO BAIDO 1, Matteo CELLA 3, Daniele LA BARBERA 1

1 Department of Biomedicine, Neuroscience, and Advanced Diagnosis, Institute of Psychiatry, University of Palermo, Palermo, Italy; 2 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; 3 Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, UK

BACKGROUND: CIRCuiTS is a computerized cognitive remediation program for individuals with schizophrenia. This study aimed to evaluate the feasibility of the Italian version of CIRCuiTS.
METHODS: Feasibility was measured through ad-hoc questionnaires in a non-clinical sample (N.=30; target-score 70%; study 1); in patients with schizophrenia (N.=5; target-score 60%; study 2) and CR therapists (N.=3; target-score 60%; study 2). Study 3 was a pilot study investigating: 1) enrolment, compliance, and retention rates; 2) satisfaction; 3) potential post-treatment and follow-up improvements in patients with schizophrenia (N.=20). These results were used to estimate sample size and feasibility for a future trial.
RESULTS: All non-clinical participants rated high feasibility of CIRCuiTS (83.3-100% scores). All patients (60-100% high-scores) and CR therapists (66-100% high-scores) evaluated CIRCuiTS feasible. High rates of retention in treatment (74.5%) and satisfaction (85-100%) in patients were showed. Post-treatment assessment revealed an improvement in all cognitive measures. A sample size of 32 was calculated for each arm of the trial, at the desired power of 80%, to recruit for 18 months.
CONCLUSIONS: Results showed the feasibility of the Italian version of CIRCuiTS, they will inform a controlled future trial and implementation study of this therapy approach in the Italian mental health system.

KEY WORDS: Schizophrenia; Computers; Metacognition; Rehabilitation; Pilot projects

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