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Minerva Psichiatrica 2007 March;48(1):1-9


language: Italian

Depression symptomatology and quality of life between 10 and 15 years after heart transplant

Martinelli V. 1, 2, Fusar Poli P. 1, 2, Klersy C. 3, Politi P. 1, 2

1 Sezione di Psichiatria Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali Università degli Studi di Pavia, Pavia 2 Servizio Psichiatrico di Diagnosi e Cura IRCCS Policlinico San Matteo, Pavia, 3 Servizio di Biometria ed Epidemiologia Clinica IRCCS Policlinico San Matteo, Pavia


Aim. The purpose of this study was to assess quality of life (QoL) and its possible demographic, clinical and therapeutic determinants, ascertain the possible prevalence of depressive symptomatology and analyse the correlation between QoL and depression over the long term following heart transplant.
Methods. The transverse observational study included all patients (329) who had received a heart transplant at the San Matteo Polyclinic of Pavia, between 1985 and 1994. Subjects alive at the moment of the follow-up and who had been transplanted between 10 and 15 years previously (96 in all) were evaluated clinically and completed the Medical Outcome Study-36-Item Short Form Health Survey (SF36) and Beck Depression Inventory (BDI) questionnaires. The data collected were analysed using descriptive statistics and general linear regression models.
Results. Between 10 and 15 years after the transplant, physical QoL is inferior to that of the normal population (P<0.001), while mental QoL is comparable. Multivariate analysis shows that a low level of physical health correlates with the presence of children and a diagnosis of kidney failure (P=0.045, P<0.001); the difference between current weight and weight at the moment of the transplant and the observation of moderate-severe hypertension, on the other hand, influence the mental dimension of QoL (P=0.001, P=0.005). Subjects with no, slight-moderate, moderate-severe or severe depressive symptomatology totalled respectively 72%, 19%, 6%, 3% with a linear correspondence between the perception of poor physical and mental condition and the level of depression.
Conclusion. The patients reported good QoL overall more than 10 years from the operation. More than 1/4 of subjects show a variable degree of depressive symptomatology, related to the perception of a worse QoL.

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