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Minerva Pneumologica 2020 March;59(1):12-9

DOI: 10.23736/S0026-4954.20.01865-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Idiopathic pulmonary fibrosis and gastroesophageal reflux

Filippo PATRUCCO 1, 2 , Ludovica VENEZIA 3, Roberta NICALI 2, Rinaldo PELLICANO 3, Mattia BELLAN 1, 4, Piero E. BALBO 2

1 Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy; 2 Division of Respiratory Medicine, Department of Medicine, AOU Maggiore della Carità di Novara, Novara, Italy; 3 Division of Gastroenterology, Molinette Hospital, Città della Salute e della Scienza, Turin, Italy; 4 Unit of Immunorheumatology, Division of Internal Medicine, Maggiore della Carità Hospital, Novara, Italy



Idiopathic pulmonary fibrosis (IPF) is a rare and progressive chronic respiratory disease. Although interconnections between gastroesophageal reflux disease (GERD) and IPF are numerous, their relationship is still controversial. Pathogenetic hypotheses involve micro-aspiration of gastric acid causing inflammation and then remodeling of lung structure until fibrosis, even to acute accelerating exacerbations of IPF. Moreover, IPF may itself aggravate GERD increasing intrathoracic pressure. Several studies have evaluated the possible beneficial effects of antacid and antireflux therapies on patients’ outcomes and pulmonary function, but results are still conflicting. This narrative review explores many aspects of the relationship between IPF and GERD, including pathogenesis, clinical implications, medical and surgical GERD therapies, summarizing the results of most important studies conducted in this specific field.


KEY WORDS: Idiopathic pulmonary fibrosis; Gastroesophageal reflux; Antireflux therapy

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