Home > Journals > Minerva Pneumologica > Past Issues > Minerva Pneumologica 2018 June;57(2) > Minerva Pneumologica 2018 June;57(2):21-6



To subscribe
Submit an article
Recommend to your librarian


Publication history
Cite this article as



Minerva Pneumologica 2018 June;57(2):21-6

DOI: 10.23736/S0026-4954.18.01813-8


language: English

Subclinical thyroid disease and obstructive sleep apnea: a focus on their relationship

Claudio ANDALORO 1 , Ignazio LA MANTIA 2

1 Ear Nose and Throat Unit, Santa Marta e Santa Venera Hospital, Acireale, Catania, Italy; 2 Department of Medical Sciences, Surgical and Advanced Technologies, University of Catania, Catania, Italy


BACKGROUND: Studies investigating the relationship between subclinical thyroid diseases and sleep disorders are limited in the literature, so in this study, we aimed to evaluate the sleep quality in patients with subclinical thyroid disease.
METHODS: Gender, age, Body-Mass Index (BMI), thyroid-stimulating hormone (TSH) and serum free T4 (fT4) levels of 123 patients with euthyroidism and subclinical thyroid disease referred to our clinic for a sleep study evaluation were studied. The Pittsburgh Sleep Quality Index (PSQI) score averages, the Apnea-Hypopnea Index (AHI) obtained by scoring polysomnography (PSG) data and the sleep apnea severity grading were recorded and used for analysis evaluation.
RESULTS: There was no statistically significant difference in the BMI Score as regards to gender and age among groups. The PSQI Score was significantly higher both in the subclinical hypothyroidism group and subclinical hyperthyroidism group when compared to the control euthyroid group (P<0.001). AHI scores were significantly higher in the two thyroid disease subgroups (23.5±10.6 for the subclinical hypothyroidism group; 19.8±8.8 for the subclinical hyperthyroidism group) when compared to the control group (7.8±5.1) (P<0.001). No statistically significant difference was found between the two thyroid disease subgroups both in terms of PSQI and AHI Score. Furthermore, a higher severity of obstructive sleep apnea syndrome (OSAS) has been shown among subclinical hypothyroidism than among subclinical hyperthyroidism or controls, when subjects were matched for AHI Score.
CONCLUSIONS: The results of our study indicate that subclinical thyroid disease affects sleep quality negatively.

KEY WORDS: Sleep apnea syndromes - Thyroid diseases - Polysomnography

top of page