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Minerva Pneumologica 2013 March;52(1):15-26

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

Non-invasive ventilation in patients with progressive neuro-muscular disorders

Vianello A., Arcaro G., Barrile D., Concas A., Paladini L.

Respiratory Pathophysiology and Intensive Care Unit, University Hospital of Padua, Padua, Italy


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Respiratory failure (RF) is a major cause of morbidity and mortality among patients with progressive neuro-muscular disorders (NMD). Although evidence from controlled trials is lacking, administration of long-term non-invasive mechanical ventilation (NIV) appears to improve physiologic parameters, the quality of life and life-expectancy. A non-invasive approach to the management of tracheo-bronchial secretions, based on the combination of expiratory muscle aid and NIV, can reduce the need for hospitalisation during chest infection, avoid intubation and facilitate extubation of patients with respiratory exacerbation, leading to significantly better outcomes.

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