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Minerva Pneumologica 2011 June;50(2):155-8

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

Severe out-of-proportion pulmonary hypertension in adult COPD patient and therapy with bosentan

Battaglieri M. 1, Cantoni A. 2

1 Cardiorespiratory Section, Geriatric Department, Istituto Pio Albergo Trivulzio, Milan, Italy 2 Geriatrics, Istituto Pio Albergo Trivulzio, Milan, Italy


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Bosentan is a dual endothelin receptor antagonist, indicated for the treatment of pulmonary arterial hypertension (PAH). This paper presents our experience with bosentan therapy in a chronic obstructive pulmonary disease patient with concomitant severe pulmonary hypertension. The therapy implemented led to a gradual reduction in pulmonary artery pressure values and an improvement in a 6-minute walk test. Good tolerance and a safety profile in line with controlled clinical studies were also observed.

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