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Minerva Pediatrics 2021 Jul 26

DOI: 10.23736/S2724-5276.21.06544-7

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Cardiometabolic risk in childhood cancer survivors

Caterina LUONGO 1, Emioli RANDAZZO 2, Lorenzo IUGHETTI 3, Natascia DI IORGI 4, Sandro LOCHE 5, Mohamad MAGHNIE 4, Giuliana VALERIO 6, Maurizio DELVECCHIO 7

1 Department of Woman, Child, General and Specialized Surgery, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy; 2 Department of Clinical and Experimental Medicine, Unit of Pediatric Endocrinology and Diabetes, University of Pisa, Pisa, Italy; 3 Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy; 4 Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genova, Italy; 5 Pediatric Endocrine Unit, Ospedale Pediatrico Microcitemico A Cao, Cagliari, Italy; 6 Department of Movement Sciences and Wellbeing, University of Naples Parthenope, Naples, Italy; 7 Metabolic Disorders and Genetic Unit, Giovanni XXIII Children Hospital, Bari, Italy


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The Italian Cancer Registry Association has estimated that for the five-year period 2016-2020, in line with the previous five years, approximately 7,000 neoplasms have been diagnosed among children and 4,000 among adolescents. Leukemias, brain tumors and lymphomas together account for more than two-thirds of all pediatric cancers. Fortunately, the five-years survival rate has progressively improved reaching 80% thanks to the continuing improvement of therapeutic protocols but the vast majority of these cancer survivors will have at least one chronic health condition by 40 years of age. Long-term complications concern various organs and systems and have a multifactorial etiopathogenesis. Obesity, diabetes and metabolic syndrome represent chronic diseases that affect life expectancy. Cardiovascular risk partly linked to therapies and genetic susceptibility and partly linked to the presence of obesity, diabetes and metabolic syndrome predispose childhood cancer survivors to heart failure, coronary artery disease, valvular disease, arrhythmia. Hence the cardio- metabolic risk of childhood cancer survivors can have a significant impact on their lives, families, and on society at-large. It is therefore very important to know the risk factors that predispose to the development of cardio-metabolic pathologies in childhood cancer survivors, the possible primary and secondary prevention strategies, the methods of surveillance and the therapeutic approaches.


KEY WORDS: Metabolic syndrome; Childhood cancer survivors; Cardiovascular diseases

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