Home > Journals > Minerva Pediatrics > Past Issues > Articles online first > Minerva Pediatrics 2021 Apr 15

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

 

Minerva Pediatrics 2021 Apr 15

DOI: 10.23736/S2724-5276.21.06193-4

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Reduced antioxidant capacity in children with iron deficiency and iron-deficiency anemia

Humeyra ASLANER 1, Mehmet Akif DÜNDAR 2 , Alev ARSLAN 3, Çigdem KARAKÜKCÜ 4, Yasemin ALTUNER TORUN 5

1 Department of Pediatrics, Medical Health University Kayseri Training and Research Hospital, Kayseri, Turkey; 2 Department of Pediatrics, Erciyes University, Kayseri, Turkey; 3 Division of Pediatric Cardiology, Department of Pediatrics, Başkent University Application and Research Center, Adana, Turkey; 4 Department of Biochemistry, Medical Health University Kayseri Training and Research Hospital, Kayseri, Turkey; 5 Division of Pediatric Hematology, Department of Pediatrics, İstinye University, İstanbul, Turkey


PDF


OBJECTIVE: This study aimed to assess the relationship between antioxidant enzymes such as glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), and paraoxonase (PON1) and carotid intima-media thickness (CIMT) and investigate susceptibility to atherosclerosis with decreasing antioxidant capacity in adolescent patients with iron deficiency (ID) and irondeficiency anemia (IDA).
MATERIAL AND METHODS: Twenty-five patients with IDA (14.9±1.8 years; 14 female and 11 male patients), 25 patients with ID (14.1±2.24 years; 13 female and 12 male patients) and 21 healthy controls (14.04±2.01 years; 11 female and 10 male individuals) were included in the study. Serum PON1, GSH-Px, GSH-R, and CIMT were measured in all cases. After 3-month oral iron therapy for the group with IDA, the same measurements were performed again.
RESULTS: CIMT was statistically significantly higher in patients with ID and IDA than in the control group (p<0.05). PON1, GSH-Px, and GSH-R activities decreased and were statistically significantly low in patients with IDA compared to the control group (p<0.05). Serum PON1 activity was statistically significantly lower in patients with ID than in the control group (p<0.05). Post-treatment PON1, GSH-Px, and GSH-R activities in patients with IDA got back to normal and were statistically significantly higher compared to pre-treatment values.
CONCLUSIONS: Antioxidant capacity decreases in patients with IDA and ID, which causes atherosclerotic changes. Therefore, patients with iron deficiency must be treated without the development of iron-deficiency anemia.


KEY WORDS: Antioxidant capacity; Iron deficiency; Iron-deficiency anemia; Carotid intimamedia thickness

top of page