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Minerva Pediatrica 2020 Sep 03
DOI: 10.23736/S0026-4946.20.05748-5
Copyright © 2020 EDIZIONI MINERVA MEDICA
language: English
Oxidant and antioxidant balance in children with bacteremia
Kubra AYKAC 1, Yasemin OZSUREKCI 1 ✉, Sevgen TANIR BASARANOGLU 1, Osman O. DEMIR 2, Gamze AVCIOGLU 3, Ozcan EREL 3, Mehmet CEYHAN 1
1 Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey; 2 Department of Pediatric Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey; 3 Department of Clinical Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey
BACKGROUND: There is a crucial balance between oxidant and antioxidant defense mechanisms. We aimed to evaluate the role of the balance of these systems in children with bloodstream infection.
METHODS: We analyzed prospectively oxidant and antioxidant stress parameters from serum samples of children with BSI besides demographic and clinical data of children. Serum levels of the total antioxidant status (TAS), total oxidant status (TOS), albumin, plasma thiol, disulphide, catalase (CAT), myeloperoxidase (MPO), ischemia-modified albumin (IMA) levels, ferroxidase and arylesterase (ARES) activity were evaluated in both patients and healthy controls.
RESULTS: A total of 113 children were evaluated, 50 of them had bacteremia and the remaining 63 were healthy subjects. The median TOS values were 18.5 μmol H2O2/L and 13.1 μmol H2O2/L in patient and control groups, respectively with a statistically significant difference between groups. The mean serum IMA levels were 0.8 ± 0.1 absorbance unit (ABSU) in patients and 0.5 ± 0.09 ABSU in control, the difference between groups was statistically significant. The native thiol, total thiol levels and the disulphide levels were significantly lower in the patient group as compared with the control group. The myeloperoxidase level was 136 U/L in patients and 107 in controls with a statistically significant difference between groups.
CONCLUSIONS: TOS, IMA, MPO, and particularly plasma thiols seem good candidates for accurate diagnosis of bacteremia in children.
KEY WORDS: Biomarker; Oxidative stress; Pediatrics; Infectious disease