Home > Journals > Minerva Pediatrics > Past Issues > Minerva Pediatrica 2020 October;72(5) > Minerva Pediatrica 2020 October;72(5):416-23

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

REVIEW  NOVEL INSIGHTS INTO PEDIATRIC ALLERGY AND IMMUNOLOGY Freefree

Minerva Pediatrica 2020 October;72(5):416-23

DOI: 10.23736/S0026-4946.20.05976-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

New insights into food protein-induced enterocolitis in children

Carla MASTRORILLI 1 , Angelica SANTORO 2, Michela PROCACCIANTI 2, Giuseppe PAGLIARO 3, Carlo CAFFARELLI 2

1 Unit of Pediatric Allergy and Pulmonology, Department of Pediatrics and Emergency, Consorziale-Policlinico University Hospital, Pediatric Hospital Giovanni XXIII, Bari, Italy; 2 Department of Medicine and Surgery, Pediatric Clinic, University of Parma, Parma, Italy; 3 Pediatric Unit, Department of Obstetrics, Gynecology and Pediatrics, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy



Food protein-induced enterocolitis syndrome (FPIES) represents a non-IgE-mediated food allergic disorder with delayed gastrointestinal symptoms that may evolve in a medical emergency. Clinically, FPIES can be distinguished into acute and chronic phenotypes. FPIES is mainly diagnosed in infancy however the onset at older ages is being progressively described. The pathogenetic mechanism underlying FPIES remains mainly unexplained, but an alteration of food-specific T-cell response has been proposed. The diagnosis of FPIES is primarily clinical, since there are not available specific biomarkers. Oral food challenge (OFC) is the gold standard for diagnosing FPIES or excluding the onset of tolerance to the triggering food. Management of FPIES includes an acute phase treatment and a maintenance therapy with the strict food avoidance until challenge, in order to prevent new attacks and avoid nutritional alterations. Acute management requires hydration that can be performed orally or intravenously according to clinical status. Long-term management of FPIES is based on the avoidance of the culprit food(s) and supervised introduction of other high-risk foods if never taken before among infants before 12 months of age. There is a compelling need of future achievements in FPIES research for the definition of underlying disease pathogenesis and potential therapeutic point of care.


KEY WORDS: Child; Milk; Food hypersensitivity; Soy milk; Enterocolitis

top of page