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Minerva Pediatrica 2020 Jun 04

DOI: 10.23736/S0026-4946.20.05915-0

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Vitamin D effects and endocrine diseases

Silvia SAVASTIO 1 , Roberta CINQUATTI 1, Francesco TAGLIAFERRI 1, Ivana RABBONE 1, 2, Gianni BONA 1, 2

1 SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carità, University of Piemonte Orientale, Novara, Italy; 2 Department of Health Sciences, University of Piemonte Orientale, Novara, Italy


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A lack of vitamin D has been linked to autoimmune diseases including Type 1 diabetes (T1D), autoimmune thyroiditis and to obesity. The prevalence of vitamin D deficiency is higher in diabetic or obese children and patients with thyroiditis compared to healthy controls. Moreover, low vitamin D values seem to be associated with major complications and poor glycemic control, in particular in obese children. Supplementation with vitamin D, which has immune-regulatory properties, may support our therapies and improve the outcomes in different diseases. Although some studies suggest a possible role of vitamin D in the etiology of autoimmune diseases and obesity, data on supplementation benefits are inconclusive and further studies are needed. In this paper, we focus on the current evidence regarding vitamin D function in endocrine diseases and possible benefits of its supplementation in pediatric age.


KEY WORDS: Childhood; Vitamin D; T1D; Obesity; Thyroiditis

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