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MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


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Minerva Pediatrica 2018 Feb 23

DOI: 10.23736/S0026-4946.18.05207-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

New therapies for vascular anomalies of the GI tract

Victor L. FOX

Harvard Medical School, GI Procedure and Endoscopy Unit, Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA


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Vascular anomalies are a morphologically and biologically diverse group of vascular channel abnormalities that are often congenital but may evolve or change over time in the developing child. Classification is based on a combination of physical and biological properties and clinical behavior that differentiate primarily between tumors and malformations and includes a few provisionally unclassified lesions. Anomalies of the GI tract may present clinically with GI bleeding, abdominal pain, high-output cardiac failure, and malabsorption. This review focuses on new therapies for the treatment of GI bleeding. Important new pharmacological therapies include treatment of hemangioma with non-selective and selective beta-antagonist agents, propranolol and atenolol, and treatment of blue rubber bleb nevus syndrome and CAT/MLT with sirolimus, an inhibitor of mTOR. Therapeutic endoscopy may offer an effective alternative to bowel resection for colonic varices and other focal vascular anomalies of the GI tract that fail to respond to pharmacological therapy.


KEY WORDS: Vascular anomaly - Blue rubber bleb nevus syndrome - Hemangioma - Venous malformation - Angiogenesis - Colonic varices - Sirolimus

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Publication History

Article first published online: February 23, 2018
Manuscript accepted: February 19, 2018
Manuscript received: January 29, 2018

Cite this article as

Fox VL. New therapies for vascular anomalies of the GI tract. Minerva Pediatr 2018 Feb 23. DOI: 10.23736/S0026-4946.18.05207-6

Corresponding author e-mail

victor.fox@childrens.harvard.edu