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MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
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Minerva Pediatrica 2018 Jan 11

DOI: 10.23736/S0026-4946.18.05182-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects

Francesco DI PIERRO 1 , Paolo RISSO 2, Elena POGGI 3, Anna TIMITILLI 4, Sara BOLLOLI 4, Maurizio BRUNO 4, Egidio CANEVA 4, Riccardo CAMPUS 4, Alessandro GIANNATTASIO 5

1 Scientific and Research Department, Velleja Research, Milan, Italy; 2 Health Sciences Department, University of Genoa, Genoa, Italy; 3 Pediatrics Department, University of Genoa, Genoa, Italy; 4 Public Health Department, Genoa, Italy; 5 DI.S.T.BI.M.O., University of Genoa, Genoa, Italy


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BACKGROUND: Previous trials, performed in subjects affected by recurrent streptococcal pharyngo-tonsillar infection, have shown that the use for 90 days of Streptococcus salivarius K12 (K12), an oral colonizing probiotic producing lantibiotic bacteriocins, reduces the occurrence of streptococcal and viral pharyngitis and acute otitis media (AOM). The aim was to evaluate the role of K12 in reducing the incidence of streptococcal and viral pharyngo-tonsillitis and AOM when administered in two separate trimesters, from October to December and then from April to June, in pediatric subjects with non-recurrent streptococcal infection.
METHODS: We retrospectively analyzed the incidence of pharyngo-tonsillitis and AOM in 133 children by comparing the number of episodes occurring between September 1, 2014 and August 31, 2015, when no treatment with K12 was given, with the period between September 1, 2015 and August 31, 2016, when K12 was administered.
RESULTS: Analysis of the findings for the 133 children demonstrated that K12 use decreased the incidence of pharyngo-tonsillitis by about 90% (p<0.001) and the occurrence of AOM by about 70% (p<0.001) and confirms the high safety profile of the strain.
CONCLUSIONS: As already demonstrated in subjects with recurrent streptococcal pharyngo-tonsillar infection, K12, if administered for two trimesters out of 12 months, is associated with a reduced incidence of pharyngitis and AOM in pediatric subjects with non-recurrent streptococcal infection.


KEY WORDS: Oral probiotics - Pediatric infections - BLIS K12 - Not recurrent - Children

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Publication History

Article first published online: January 11, 2018
Manuscript accepted: January 10, 2018
Manuscript received: December 27, 2017

Cite this article as

Di Pierro F, Risso P, Poggi E, Timitilli A, Bolloli S, Bruno M, et al. Use of Streptococcus salivarius K12 to reduce the incidence pharyngo-tonsillitis and acute otitis media in children: a retrospective analysis in not-recurrent pediatric subjects. Minerva Pediatr 2018 Jan 11. DOI: 10.23736/S0026-4946.18.05182-4

Corresponding author e-mail

f.dipierro@vellejaresearch.com