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MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


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Minerva Pediatrica 2017 May 31

DOI: 10.23736/S0026-4946.17.04994-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The significance of genetics in pathophysiologic models of premature birth

Jose UBEROS

Neonatal Unit, Hospital Clínico San Cecilio, Granada, Spain


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Prematurity is a major health problem in all countries, especially in certain ethic groups and increasing recurrence imply the influence of genetic factors. Published genetic polymorphisms are identified in relation to the 4 pathophysiological models of prematurity described: Chorioamniotic-decidual inflammation, premature contraction pathway, decidual haemorrhage and susceptibility to environmental toxins. 240 articles are identified, 52 articles are excluded because they are not original, not written in English or duplicated. From them 125 articles were included in qualitative analysis This review aims to update recent knowledge about genes associated with premature birth.


KEY WORDS: Prematurity - Genetics - Epidemiology - Review

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Uberos J. The significance of genetics in pathophysiologic models of premature birth. Minerva Pediatr 2017 May 31. DOI: 10.23736/S0026-4946.17.04994-5 

Corresponding author e-mail

juberos@ugr.es