Home > Journals > Minerva Pediatrica > Past Issues > Articles online first > Minerva Pediatrica 2017 May 04

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints
Cite this article as

MINERVA PEDIATRICA

A Journal on Pediatrics, Neonatology, Adolescent Medicine,
Child and Adolescent Psychiatry


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,764


eTOC

 

Minerva Pediatrica 2017 May 04

DOI: 10.23736/S0026-4946.17.04847-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Associations of seasonal patterns and vitamin D levels with onset and flares of pediatric inflammatory bowel disease

Yael BRANDVAYMAN 1, Firas RINAWI 2, Raanan SHAMIR 1, 2, Amit ASSA 1, 2

1 Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 2 Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children’s Medical Center, Petach-Tikva, Israel


PDF  


BACKGROUND: As inflammatory bowel disease (IBD) might be associated with environmental factors such as seasonal patterns and low vitamin D levels we aimed to assess their association with IBD onset and flares in a large cohort of children.
METHODS: The records of 623 pediatric onset IBD patients were reviewed retrospectively including age at onset, gender, severity indices, month of first symptom, and vitamin D levels at diagnosis. For a subgroup of patients, data included date of first flare and vitamin D levels during flare and remission.
RESULTS: Median age at diagnosis was 14 years (IQR 11.66 - 15.58). Disease onset did not vary significantly between either month (p=0.367) or seasons (p=0.460). Vitamin D deficiency at the time of diagnosis was prevalent in 21% of patients with no significant association with month, season or disease's type. Vitamin D deficiency was significantly more prevalent in patients with malnutrition (p<0.001) and was associated with hypoalbuminemia (p=0.02) but did not correlate with low bone mineral density. Analysis of 169 first flares showed that flares were more common in June and less common in April (p=0.016). Mean vitamin D level was significantly lower during flares compared with remission (55.25±19.28 vs. 64.16±26.6, respectively, p=0.012).
CONCLUSIONS: IBD onset in school aged children is not associated with seasonal patterns whereas flares may follow a specific monthly pattern. Disease flares are associated with low vitamin D blood levels. Vitamin D deficiency is associated with malnutrition and hypoalbuminemia.


KEY WORDS: Crohn's disease - Ulcerative colitis - Seasonality

top of page

Publication History

Cite this article as

Brandvayman Y, Rinawi F, Shamir R, Assa A. Associations of seasonal patterns and vitamin D levels with onset and flares of pediatric inflammatory bowel disease. Minerva Pediatr 2017 May 04. DOI: 10.23736/S0026-4946.17.04847-2 

Corresponding author e-mail

dr.amit.assa@gmail.com