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Minerva Pediatrica 2016 Dec 22

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Iron parameters, prohepcidin and soluble transferrin receptor levels in obese children

Güzide DOĞAN 1, Nesibe ANDIRAN 2, Nurullah ÇELİK 3, Sema UYSAL 4

1 Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey; 2 Department of Pediatric Endocrinology, Faculty of Medicine Yıldırım Beyazıt University, Keçiören Training and Research Hospital, Ankara, Turkey; 3 Department of Pediatric Endocrinology, Faculty of Medicine Fatih University, Ankara, Turkey; 4 Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey


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BACKGROUND: Iron deficiency is common in obese children although the underlying mechanism is unclear. Several studies have investigated the relation between iron deficiency and obesity, but studies focusing on children are rare. The aim was to investigate the associations between iron parameters, prohepcidin and soluble transferrin receptor levels in obese children.
METHODS: A total of 110 children, ranging in age from 6-16, 50 with primary obesity and 60 healthy children and adolescents, were enrolled. Complete blood count, serum iron levels, iron binding capacity, ferritin levels, soluble transferrin receptor, and prohepcidin levels were studied.
RESULTS: Serum iron and transferrin saturation index levels were significantly low, red cell distribution width and ferritin levels were significantly high in obese children compared to control group. No association between soluble transferrin receptor, prohepcidin and iron parameters was detected. A positive correlation between ferritin and prohepcidin levels was defined.
CONCLUSIONS: Obese children and adolescents were at greater risk for ıron deficiency. It should be considered in the diet recommendations.


KEY WORDS: Obesity - Iron deficiency - Soluble transferrin receptor - Prohepcidin - Children - Adolescents

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