Home > Journals > Minerva Pediatrica > Past Issues > Articles online first > Minerva Pediatrica 2015 Sep 17

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Cite this article as

 

 

Minerva Pediatrica 2015 Sep 17

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Isoniazid-induced hepatotoxicity in children with latent tuberculosis infection

Devrim I. 1, Devrim F. 2, Aktürk H. 1, Kara A. 1, Bayram N. 1, Can D. 3, Apa H. 1

1 Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children’s Hospital, İzmir, Turkey; 2 Department of Pediatrics, Dr. Behçet Uz Children’s Hospital, İzmir, Turkey; 3 Pediatric Allergy and Asthma Unit, Ankara, Turkey., Dr. Behçet Uz Children’s Hospital, İzmir, Turkey


PDF


OBJECTIVES: We aimed to determine overall incidence of severe and mild isoniazid (INH) hepatotoxicity and outcome of hepatotoxicity in children who were receiving INH for latent tuberculosis.
METHODS: Patients who had received isoniazid for treatment of latent tuberculosis were included in the study. Hepatotoxicity was classified according to the World Health Organization Toxicity Classification Standards.
RESULTS: Among 1038 patients, overall hepatotoxicity was observed in 23 patients (2.2 %), while 5 patients (0.48 %) had moderate – severe hepatotoxicity; while other 18 patients had grade I – II hepatotoxicity (1.73%). Age and gender did not appear to be risk factors for hepatotoxicity. The median time for therapy rechallenge in patients with grade III – IV hepatotoxicity was 21 days (ranging from 14 to 25 days).
CONCLUSIONS: Isoniazid hepatotoxicity is lower and generally reversible after cessation of INH in children. The grade of hepatotoxicity affects the duration for recovery of hepatotoxicity and restarting of INH therapy.

top of page